ZM 306416

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ZM 306416 是 VEGFR1 的 VEGFR（Flt 和 KDR）抑制剂，IC50 为 0.33 μM，但也能抑制 EGFR，IC50 <10 nM。

ZM 306416 is a VEGFR (Flt and KDR) inhibitor for VEGFR1 with IC50 of 0.33 μM, but also found to inhibit EGFR with IC50 of <10 nM.

ZM-306416 selective anti-proliferative effect toward the EGFR addicted NSCLC cell lines H3255 and HCC4011 (IC50=0.09±0.007 μM and 0.072±0.001 μM respectively), while sparing the wild type EGFR cell lines A549 and H2030 (IC50>10 μM). ZM-306416 is also found to inhibit the ABL in vitro kinase activity with a less potent IC50 value of 1.3±0.2 μM toward the ABL kinase.

——

CB-676475

Tyrosine Kinase

Bcr-Abl

Abl| Src| VEGFR1

Cancer

——

690206-97-4

333.74

C16H13ClFN3O2

>98% (HPLC)

DMSO: 67 mg/mL (200.75 mM)

COC1=CC2=NC=NC(NC3=CC=C(Cl)C=C3F)=C2C=C1OC

4-[(4'-Chloro-2'-fluoro)phenylamino]-6,7-dimethoxyquinazoline

(-20℃)

With Ice Pack

≥ 2 years